Role of the lipotoxicity in glycemic control achieving
AbstractObjective: To improve management of type 2 diabetes mellitus by influencing of the lipotoxicity.
Materials and Methods: The study involved 77 patients with type 2 diabetes mellitus with bad glycemic control (HbA1c 7,5–11%) on OADs prior therapy.Along OADs treatment, all patients were assigned Reduxine 10 mg/day. The duration of follow-up was 6 months, during which two visits were conducted: The enrolment and ending. The primary indicator of efficiency was the changing body fat from baseline to 24th week of the research, also leptin levels, TG level and FFA. Also estimated tolerability and adherence to the therapy.
Results: As a result of medical treatment to the end of 24th week of the research the average body fat in the whole group was significantly reduced: at 10,0% (p<0,001). Thus, the high efficiency of combined drugs reduxin and OADs. By the end of 24 weeks of study, there was a significant decrease of the leptin in the whole group made up to 71,8% (p<0,001), and FFA level at 20,3% (p<0,001), and TG levels in the blood at 28,2% (p<0,05), as a consequence – reducing of the adipose tissue amount. In addition, it is good tolerability of the combined therapy with reduxin and oral antidiabetic drugs. More than 90% of patients were satisfied with the therapy and want to continue it.
Conclusions: The data analysis obtained in the course of our investigation showed that treatment with reduxin in combination with oral antidiabetic drugs (metformin) that in addition to weight loss, and related indicators (waist, hips, BMI, body fat), at patients with type 2 diabetes mellitus and obesity, a statistically significant decrease ofleptin and the related decrease in the concentration of FFA and TG. Provided data suggest the gradual compensation of lipid metabolism in adipose tissue and, consequently, thelipotoxicity reduce.
Keywords:diabetes mellitus type 2, obesity, lipotoxicity