The effect of derivative bicyclic bisurea on lipid metabolism in patients with angina FC I-III
Keywords:angina, anxiety disorder, depression, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides
Objective: to determine the influence of adaptol, the company OlainFarm, Latvia) on lipid metabolism in patients with coronary artery disease angina FC I-III. Research methods: clinical and historical data, ECG in 12-lead ECG, daily Holter ECG monitoring, Bicycle ergometry, determination of total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, questionnaires for evaluation of anxiety/depression HADS, Ces-D, Buck.
Results: the study included 104 patients with coronary artery disease angina FC I-III in aged from 34 to 71 years, who were divided into 3 groups. In the I group consisted of 42 patients with coronary artery disease, angina FC I-III with anxiety disorders, in some cases in conjunction with depression, which was administered adaptol 500 mg 2 times a day for two months; in the II – 43 patients with CHD, angina FC I-III without anxiety disorders, who was therapy adaptol 500 mg 2 times a day for two months; III - the control group consisted of 19 patients with coronary artery disease, angina FC I-III without anxiety disorders, whom treatment adaptol not been conducted. In each group, baseline, 1, 2 and 3 months were all methods of examination. The level of total cholesterol decreased significantly within a month after the treatment with 5,33±0,19 to 4,76±0,13 (p<0,05) in group I and 6,24±0.21 to 5,39±0,22 (p<0,05) in group II, the level of LDL cholesterol from 3,24±0,16 to 2,62±0,17 (p<0,05) in group I and from 3,65±0,20 to 3,02±0,19 (p<0,05) in group II. The level of triglycerides decreased after a month in patients of group II with 1,61±0,09 to 1,24±0,08 (p<0,05). This trend continued during the whole treatment adaptol and effect decreased, but not to the original values, a month after stopping treatment.
Conclusions: adaptol in patients with angina FC I-III reduces the level of total cholesterol, LDL cholesterol, triglycerides while taking it regardless of the presence or absence of anxiety disorders.