The relationship between erectile function and lipotoxicity

• M.V. Stelmakh

Abstract

Aim: to study the characteristics of clinical and laboratory parameters in obese men.

Materials and Methods: the study included 31 men aged 30 to 55 years (mean age 43,7 years). At baseline, all patients had a diagnosis of obesity (BMI30). Mean body mass index was 38,6 kg/m2. For the clinical assessment questionnaires were used International Index of Erectile Function-5 (IIEF-5), Questionnaire symptoms of aging men (AMS), Hospital Anxiety and Depression Scale (HADS). As a result of the survey, patients were divided into three clinical groups. The first group consisted of 18 patients with mild erectile dysfunction (ED), 8 patients with moderate ED and 3 Group 5 people with severe ED.

Findings: all patients had a significantly greater degree of abdominal obesity: waist circumference (WC): first group: 123,5±15; second group: 129,6±26,6 and third group: 132,2±9,2 cm and body mass index (BMI): 40,1±9,9 and 40,25±9,85 and 41,84±5,84 respectively. We have identified a correlation that with increasing waist circumference and body mass index progresses severity of erectile dysfunction. Also, Leptin levels were significantly higher in all patients: first group: 41,66±19,73, second group: 47,5 ±20,35, third group: 42,57±0,3 ng/ml. In all groups were found hypertriglyceridemia with most severe in the third group: 3,68±2,44 respectively; 2,2±0,8 respectively; 4,3±0,9 mmol/l respectively. In assessing the results of hormonal studies we found that the lowest total (TT) and free testosterone (FT) and the highest estradiol (E) were in the group with severe erectile dysfunction: TT: 2,98±1,78, 2,8±3,01, 1,94 ±0,58 ng/ml respectively; FT: 65±42,3, 61±49,1, 38±13 pg/ml respectively; E: 32,9 ± 18,1, 42,8 ±28,8, 50,44±5,4 pg/ml respectively. According to the results of the survey in all groups were identified subclinical symptoms of anxiety/depression and in the 2nd and 3rd groups symptomatic androgen deficiency.

Keywords:obesity, lipotoxicity, erectile dysfunction

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