Diabetes mellitus and oxidative stress

• Alexander S. Ametov
• Alimova G.U.

AbstractMain pathogenetic mechanisms of diabetes mellitus and its complications development are processes of freeradical oxidation. Substances with antioxidant activity of naturally occurring are actively studied as an additional metabolic support of diabetes mellitus. Among other naturally occurring substances with strongly pronounced antioxidant, properties are chlorogenic acids. Along with the antioxidant properties chlorogenic acids have hypoglycemic and hypolipidemic effects, decrease cardiovascular diseases development risk and decrease arterial tension and weight. One of the richest sources of chlorogenic acids for human body is green coffee. During clinical trials, «Glukoberry» was studied. It has completely vegetation composition and including necessary quantity of chlorogenic acids. Research findings showed that «Glukoberry» application as an additional metabolic therapy of diabetes mellitus type 2 improving indices of glycemia and blood lipids, also it decrease arterial tension and body-weight index. Thus, regular usage of antioxidants should be part of patients with diabetes mellitus combination therapy and prevention of diabetes mellitus complication. Usage of medications with antioxidant activity at pre-diabetes stage can help to delay disease development.

Keywords:diabetes mellitus type 2, chronic hyperglycemia, oxidative stress, free-radical oxidation, lipid peroxidation processes, free radicals, antioxidants, chlorogenic acids, multifactorial management

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