Pierre Marie`s Disease. Past and present
AbstractThe review is devoted to memorable date - 130-year registration of new medical entity - acromegaly, which is, due to its author P. Marie, not only promoted determination of physiological and pathological role of hypophysis in life activities, but also created conditions for development of efficient methods of diagnosis and treatment for previously incurable disease. The historical analysis of scientific understanding of acromegaly's etiopathogenesis, clinical and pathomorphological characteristics of growth hormone-secreting adenomas, scenarios of clinical course of the disease is performed. Surgical and therapeutic methods of treatment for acromegaly and indications for them are discussed. Comparative characteristics of modern drugs and optimal regimens of drug therapy consistent with receptor expression patterns, intensity of hormonal and proliferative activity of adenomatous cells are represented. Current international guidelines for laboratory and instrumental diagnosis of acromegaly and treatment algorithms are included.
Keywords:acromegaly, Pierre Marie's disease, growth hormone
Endocrinology: News, Opinions, Training. 2017; (1): 11–25.
DOI: 10.24411/2304-9529-2017-00021