Relationship of biologically active testosteron with vascular stiffness in postmenopausal women

• Magkaeva O.V.
• Ulubieva E.A.
• Avtandilov A.G.

Abstract

The aim of the study was to rate impact of the biologically active testosteron to vascular stiffness in women with age.

Material and methods. Patients were divided into 2 groups: 1 group - 30-35 years old women with stored menstrual function in the second phase of the menstrual cycle; 2 group - 50-55 years old women with menopausal period 2-5 years. All women have conducted daily blood pressure study, defined stiffness index, central aortic pressure, blood flow indicators were studied by method of volumetric compression oscillometryin, indicators of vascular stiffness were studied by method of photoplethysmography, they also determined the level of androgen and estrogens.

The results. The study found that vascular stiffness develop in women without risk factors in postmenopause, increases the modulus of elasticity, augmentation index, decreases the level of biologically active androgens and estrogens.

Conclusion. Free androgen index at physiological concentrstions is more informative indicator predicting the aging speed of vessels, than total testosterone.

Keywords:women, postmenopause, vascular stiffness, free androgen index, stiffness index, give of the vascular system

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