Evaluation of C-peptide secretion effect on microcirculation parameters in type 2 diabetes mellitus

• Suchkova O.V.
• Gurfinkel’ Yu.I.
• Sasonko M.L.

AbstractWe evaluated microcirculation parameters in patients with diabetes mellitus type 2 by digital capillaroscopy depending on the C-peptide secretion level. 1st group included patients with C-peptide <1000 pmol/l and 2nd group was consisted of patients with C-peptide≥1000 pmol/l. To minimize the effects of hyperglycemia on comparison results we formed both groups with similar glycemic control (8.37+0.41% in the 1st group and 8.20+0.38 in the 2nd group). The expansion of arterial segments (p<0.001), apex segments (p<0.001) and venous segments of the capillaries (p<0.05) were founded in the group with high C-peptide secretion. High C-peptide secretion patients were characterized by obesity 34.9+0.9 kg/m2 (p<0.05) and arterial hypertension (p<0.001). Elevated values of blood pressure in this group demonstrate the negative impact of high C-peptide secretion on the endothelium macrocirculation properties, in contrast to its effect on capillary component.

Keywords:digital nailfold capillaroscopy, blood microcirculation, type 2 diabetes mellitus, glycated hemoglobin, C-peptide secretion, all segments capillary enlargement (arterial, apex, venous segments)

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