Obesity: controversial issues that define metabolic health

• Filatova G.A.
• Tatyana I. Depyui
• Grishina T.I.

AbstractObesity and its relation to various metabolic disorders are the focal point of a modern medical science and healthcare. Especially significant for clinicians is the research of new indicators that are used to foresee the development of complications for overweight and obese patients. This overview defines primary aspects that reflect metabolic health of overweight and obese patients. Distribution peculiarities and dysfunction of adipose tissue play the main role in insulin resistance development, and allow to measure the risks related to obesity and cardio-metabolic diseases on an individual level. Despite the fact that metabolically healthy obese people are relatively protected from chronic disorders if compared to metabolically unhealthy people, they still at a high risk of developing obesity-related diseases compared to people with normal weight. Detailed metabolic phenotype test results of obese individuals, will play a great role in understanding the pathophysiology of metabolism disorders, and will be crucial in identifying individuals or subgroups that are at a high risk, thus optimizing the strategy of prevention and treatment to combat cardiometabolic diseases.

Keywords:obesity, body mass index, function of adipose tissue, insulin resistance, metabolically healthy obese

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