Pulmonary embolism in patients with obesity and diabetes

• Gorlovа A.A.
• Vasiltseva O.Ya.
• Vorozhtsova I.N.

Abstract

The aim of the study - to conduct a comparative analysis of the development of pulmonary embolism in individuals with obesity and diabetes according to the materials of the case histories and autopsy protocols of autopsies of deaths in hospitals in Tomsk in the period from 01.01.2013 to 31.12.2016.

Material and methods. A total of 4747 patients who were subjected to autopsies died in hospitals in Tomsk during the study period. Pulmonary embolism was detected in 320 (6.8%) deceased patients. The analysis of 180 positions was carried out to identify the key predictors of pulmonary embolism risk in metabolic disorders (obesity, type 2 diabetes, atherosclerotic process). Statistical processing was carried out using software packages SAS 9 and SPSS 21.

Results and discussion. Obesity was associated with a 2-fold increase in the risk of pulmonary embolism, compared with persons with normal body weight. Multiple atherosclerotic lesions of the aorta with atherosclerotic plaques at different stages of development turned out to be characteristic for the group of pulmonary embolism with obesity (p=0.04). The combination of obesity and diabetes mellitus was associated with an increase in the risk of pulmonary embolism by 2 times, compared with persons with diabetes mellitus without obesity.

Conclusion. Obesity was associated with an increase in the risk of pulmonary embolism in 2 times. In patients with diabetes, atherosclerotic aortic lesions were associated with an increased risk of pulmonary embolism by 3 times.

Keywords:embolism, diabetes mellitus, obesity, atherosclerosis

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