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2 . 2019

Obesity as a non-infectious epidemic of the XXI century. Modern ideas about the pathogenesis, risks and approaches to pharmacotherapy

Abstract

The article considers in detail the mechanisms of obesity development as well as epidemiological and pathogenetic aspects of the link between obesity and metabolic disorders, including type 2 diabetes. Currently Reduxin Forte is registered on the Russian pharmaceutical market, which is a fixed combination of sibutramine and metformin in a single tablet. Arguments are presented that indicate the potential safety and efficacy of a fixed combination of sibutramine and metformin in the treatment of not only obesity, but also of the metabolic syndrome, type 2 diabetes mellitus or pre-diabetes.

Keywords:obesity, diabetes mellitus type 2, sibutramine, metformin, insulin resistance, adipose tissue

For citation: Ametov A.S., Pashkova E.Yu., Ramazanova Z.D., Darsigova M.N. Obesity as a non-infectious epidemic of the XXI century. Modern ideas about the pathogenesis, risks and approaches to pharmacotherapy. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2019; 8 (2): 57-66. doi: 10.24411/2304-9529-2019-12007. (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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