1 . 2020

The antioxidant activity of androgen therapy is the basis for preventing complications in men with the type 2 diabetes mellitus

Olga A. Rozhdestvenskaya

Abstract

The review presents modern methods of early prevention of vascular complications in patients with the type 2 diabetes mellitus.

Testosterone improves metabolic risk factors for cardiovascular diseases, including body composition, cell sensitivity to insulin, antioxidant activity, and carbohydrate and fat metabolism. Early administration of transdermal forms of testosterone in physiological doses has been shown to improve metabolic and antioxidant biomarkers of blood plasma. Thus, androgen replacement therapy aimed at restoring target physiological levels of testosterone should be considered as an important strategy for preventing vascular complications in patients with the type 2 diabetes mellitus.

Keywords:type 2 diabetes mellitus, obesity, testosterone, androgen replacement therapy, men health

Funding. The study had no sponsor support.

Conflict of interests. The author declare no conflict of interests.

For citation: Rozhdestvenskaya O.A. The antioxidant activity of androgen therapy is the basis for preventing complications in men with the type 2 diabetes mellitus. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2020; 9 (1): 52-9. doi: 10.33029/2304-9529-2020-9-1-52-59 (in Russian)

References

1. Kennedy B.K., Berger S.L., Brunet A., Campisi J., Cuervo A.M., Epel E.S., et al. Geroscience: linking aging to chronic disease. Cell. 2014; 159 (4): 709-13. doi: 101016/j.cell.2014.10.039

2. Wu F.C., Tajar A., Pye S.R., Silman A.J., Finn J.D., O’Neill T.W., et al. Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study. J Clin Endocrinol Metab. 2008; 93: 2737-45.

3. Araujo A.B. Clinical review: endogenous testosterone and mortality in men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011; 96 (10): 3007-19.

4. Ruige J.B. Endogenous testosterone and cardiovascular disease in healthy men: a meta-analysis. Heart. 2011; 97 (11): 870-5.

5. Zarotsky V., Huang M.Y., Carman W., Morgentaler A., Singhal P.K., et al. Systematic literature review of the risk factors, comorbidities and consequences of hypogonadism in men. Andrology. 2014; 2: 819-34.

6. Lesser M.A. Testosterone propionate therapy in one hundred cases of angina pectoris. J Clin Endocrinol Metab. 1946; 6: 549-57.

7. Jaffe M.D. Effect of testosterone cypionate on post exercise ST segment depression. Eur Heart J. 1977; 39: 1217-22.

8. Wu S.Z., Weng X.Z. Therapeutic effects of an androgenic preparation on myocardial ischemia and cardiac function in 62 elderly male coronary heart disease patients. Chin Med J (Engl). 1993; 106: 415-8.

9. English K.M., Steeds R.P., Jones T.H., Diver M.J., Channer K.S. Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation. 2000; 102: 1906-11.

10. Malkin C.J., Pugh P.J., Morris P.D., Kerry K.E., Jones R.D., et al. Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart. 2004; 90: 871-6.

11. Cornoldi A., Caminiti G., Marazzi G., Vitale C., Patrizi R., et al. Effects of chronic testosterone administration on myocardial ischemia, lipid metabolism and insulin resistance in elderly male diabetic patients with coronary artery disease. Int J Cardiol. 2010; 142: 50-5.

12. Webb C.M., Elkington A.G., Kraidly M.M., Keenan N., Pennell D.J., et al. Effects of oral testosterone treatment on myocardial perfusion and vascular function in men with low plasma testosterone and coronary heart disease. Am J Cardiol. 2008; 101: 618-24.

13. Jones T.H., Kelly D.M. Randomized controlled trials - mechanistic studies of testosterone and the cardiovascular system. Asian J Androl. 2018; 20 (2): 120-30.

14. Wang X.F., Wang J.H., Li J.Y. Androgen deficiency in elderly men with systolic chronic heart failure. J Geriatr Cardiol. 2010; 7: 138-42.

15. Jankowska E.A., Filippatos G., Ponikowska B., Borodulin-Nadzieja L., Anker S.D., et al. Reduction in circulating testosterone relates to exercise capacity in men with chronic heart failure. J Card Fail. 2009; 5: 442-50.

16. Pugh P.J., Jones T.H., Channer K.S. Acute haemodynamic effects of testosterone in men with chronic heart failure. Eur Heart J. 2003; 24: 909-15.

17. Kelly D.M., Jones T.H. Testosterone: a vascular hormone in health and disease. J Endocrinol. 2013; 217: R 47-71.

18. Muraleedharan V, Jones TH. Testosterone and mortality. Clin Endocrinol (Oxf). 2014; 81 (4): 477-87.

19. Magnussen L.V., Glintborg D., Hermann P., et al. Effect of testosterone on insulin sensitivity, oxidative metabolism, and body-composition in aging men with type 2 diabetes on metformin monotherapy. Diabetes Obes Metab. 2016; 18 (10): 980-9.

20. Kayama Y., Raaz U., Jagger A., et al. Diabetic cardiovascular Disease induced by oxidative stress. Int J Mol Sci. 2015;16 (10): 25234-63.

21. Tiwari B.K., Pandey K.B., Abidi A.B., Rizvi S.I. Markers of oxidative stress during diabetes mellitus. J Biomark. 2013; 2013: 378790.

22. Yang J., Zong X., Wu G., Lin S., Feng Y., Hu J. Taurine increases testicular function in aged rats by inhibiting oxidative stress and apoptosis. Amino Acids. 2015; 47 (8): 1549-58.

23. Higuchi M., Celino F.T., Shimizu-Yamaguchi S., Miura C., Miura T. Taurine plays an important role in the protection of spermatogonia from oxidative stress. Amino Acids. 2012; 43(6): 2359-69.

24. Fatani A.J., Al-Rejaie S.S., Abuohashish H.M., Al-Assaf A., Parmar M.Y., Ahmed M.M. Lutein dietary supplementation attenuates strepto-zotocin-induced testicular damage and oxidative stress in diabetic rats. BMC Complement Altern Med. 2015; 15: 204.

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

Diabetes. Lifestyle

CHIEF EDITOR

Ametov Alexander S.

Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)

Buy a number Subscribe