Insulinoma - the complexity of diagnosis

• Larisa V. Kondratyeva
• Alina P. Misharova
• Larisa A. Rogova

Abstract

Insulinoma - is tumor, producing insulin, originating from β-cells of the Langerhans islets, leading to the development of hypoglycemic seizures. Insulinoma - is a rare disease, in 90% cases is benign tumor of pancreatis. Clinical manifestations of hypoglycemia are often interpreted as a pathology of the nervous system, which in some situations makes it difficult to diagnose. So, in the presented clinical case, a patient with suspected epilepsy was diagnosed with insulinoma. Surgical resection - is the main treatment of insulinomas. This patient underwent laparoscopic enucleation of insulinoma, which allowed to maintain healthy pancreatic tissue.

Keywords:insulinoma, insulin-producing tumor, hyperinsulinism, hypoglycemia

References

1. Clinical Endocronology: Lidershuip. 3^rd ed. Edited by N.T. Starkova. St. Petersburg: Piter, 2002: 576 p. (in Russian)

2. Khatsimova L.S., Karonova T.L., et al. Insulinoma: diagnostic approaches and medical practice. Problemy endocrinologii [Problems of Endocrinology]. 2017; 63 (4): 212-8. https://doi.org/10.14341/ probl2017634212-218 (in Russian)

3. Krivko A.A., Melnichenko G.A., Kusnetsov N.S., Troshina E.A., Dedov I.I. Modern technologies in diagnosis and treatment insulonomas. Problemy endocrinologii [Problems of Endocrinology]. 2013; (5): 36-41. (in Russian)

4. Endocrinology: National lidership. Edited by Dedov I.I., Melnichenko G.A. Moscow: GEOTAR-Media; 2016: 1142 p. (in Russian)

5. Демидова Т.Ю., Титова В.В. Длительно протекающий рецидив инсулиномы в клинической практике // РМЖ. Эндокринология. 2018. № 11. С. 122-125.

6. Шевченко Ю.Л., Карпов О.Э., Стойко Ю.М., Левчук А.Л., Сте-панюк И.В., Седов А.Ю. Современная диагностика и хирургическая тактика при инсулиномах поджелудочной железы // Вестник Национального медико-хирургического центра им. Н.И. Пирогова. 2016. № 1. URL: https://cyberleninka.ru/article/n/sovremennaya-diagnostika-i-hirurgicheskaya-taktika-pri-insulinomah-podzheludochnoy-zhelezy.

7. Yao J.C., Shah M.H., Ito T. et al. RAD 001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group. Everolimus for advanced pancreatic neuroendocrine tumors // N. Engl. J. Med. 2011. Vol. 364. P 514-523.

5. Demidova T.Yu., Titova V.V. Long-standing relapse of insulinoma in clinical practice. RMJ. 2018; (11): 122-5. (in Russian)

6. Shevchenko Yu.L., Karpov O.E., Stoyko Yu.M., Levchuk A.L., Stepa-nyuk I.V., Sedov A.Yu. Modern diagnostics and surgical tactics for pancreatic insulinomas. Vestnik Natsionalnogo mediko-khirurgicheskogo tsentra imeni N.I. Pirogova [Bulletin of the National Medical and Surgical Center named after N.I. Pirogov]. 2016; (1). URL: https://cyberleninka.ru/article/n/ sovremennaya-diagnostika-i-hirurgicheskaya-taktika-pri-insulinomah-podz-heludochnoy-zhelezy (in Russian)

7. Yao J.C., Shah M.H., Ito T., et al. RAD 001 in Advanced Neuroendocrine Tumors, Third Trial (RADIANT-3) Study Group. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med. 2011; 364: 514-23.

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