The role and point of the disturbed redox balance in the development of diabetic neuropathy and antioxidant effects of alpha-lipoic acid

• Alexander S. Ametov
• Anyuta A. Kosyan

Abstract

The article provides an analytical review of studies describing the mechanisms of disturbances in the redox balance of an organism under hyperglycemia, and their influence on the occurrence and progression of diabetic neuropathy, as well as the point and role of antioxidants, in particular alpha lipoic acid, in the treatment of diabetic neuropathy.

In addition, the article presents the experience of treating a patient with sensorimotor diabetic polyneuropathy using the drug alpha lipoic acid. Course therapy with alpha lipoic acid (10 infusions for 600 mg) Led to the normalization of the electrophysiological parameters of the examined nerves. The result of the study demonstrated not only positive dynamics of neuromuscular conduction and improved endothelial function at the end of therapy, but also an increase in the level of antioxidant enzymes - superoxide dismutase (+6.88% initial) and glutathione peroxidase (+44.1% initial), which once again demonstrates the efficiency and safety of alpha lipoic acid in patients with diabetic neuropathy.

Keywords:diabetes mellitus, diabetic neuropathy, endothelial dysfunction, oxidative stress, alpha lipoic acid

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