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4 . 2020

Glucose homeostasis and metabolic flexibility in healthy individuals

Abstract

Multifactorial management of type 2 diabetes implies a close approximation to normal physiology.

This article presents an analytical review of the literature on glucose homeostasis and metabolic flexibility in healthy individuals under various conditions, as well as the results of our own observational study on this topic.

Aim – to evaluate the characteristics of glycemic fluctuations in healthy individuals under various physiological conditions.

Material and methods. The study included 15 female volunteers with normal body weight and without disturbances in carbohydrate metabolism. For four days, using a continuous glucose monitoring system in a blind mode, the fluctuations in glucose in the interstitial fluid were recorded against the background of a standard oral glucose tolerance test, fasting and physical exertion (intensive walking, tests with a ladder, bicycle ergometry according to the Bruce protocol). The obtained data were statistically processed with subsequent analysis of the results.

Results and discussion. In healthy individuals against the background of glucose load, fasting and standardized physical activity, blood sugar indicators were in a strict target range. Estimated average glucose – 5.09±0.38 mmol/l (minimum blood glucose – 3.66±0.32 mmol/l; the maximum level glucose –7.15±0.95 mmol/l). Not a single case of exceeding the upper threshold of the glucose norm or its decrease <3.1 mmol/l was registered.

Keywords:glucose homeostasis, insulin secretion, fasting glycemia, food intake, fasting, exercise, continuous glucose monitoring

Funding. The study had no sponsor support.

Conflict of interests. The authors declare no conflict of interests.

For citation: Ametov A.S., Pugovkina Ya.V. Glucose homeostasis and metabolic flexibility in healthy individuals. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2020; 9 (4): 12–22. https://doi.org/10.33029/2304-9529-2020-9-4-12-22 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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