Male hyperestrogenism. Artificial problem or existing reality? Are aromatase inhibitors effective and safe?

• Zukhra Sh. Pavlova
• Armais A. Kamalov
• Ivan I. Golodnikov

Abstract

One of the global medical problems of today, besides obesity, type 2 diabetes mellitus and cardiovascular diseases, is the problem of testosterone deficiency in men, which develops at a pretty young age. Often, under the absolute lack of testosterone masked excess activity of the enzyme aromatase, leading to a decrease in the level of testosterone in the blood and increase at his influence of the level of estrogen. Only a small number of specialists analyze estrogens in men and do not perceive the lack of testosterone for its absolute deficiency and is aware of the unfounded use of testosterone replacement therapy in this case. Given the lack of indications and recommendations for determining the level of estrogen in the blood, and data from clinical studies on this topic objectifying the problem of hyperestrogenism and the safety of using aromatase inhibitors or other means that contribute to the normalization of the balance of hormones, the relevance of work in this aspect is increased.

The aim of our work was to systematize the available literature data, to draw the attention of specialists to the problem of hyperestrogenism and to offer possible solutions to the excess estrogen in men.

Keywords: hyperestrogenism, aromatase, aromatase inhibitors, estrogen receptor

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