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2 . 2021

Vitamin D deficiency: gender characteristics

Abstract

Studies assessing vitamin D status are relevant both in the world and in the Russian Federation to determine the frequency of 25(OH)D deficiency, the severity of vitamin D metabolism disorders and focus populations with the greatest problems in vitamin D supply. We have shown that men are extremely rare determine the status 25(OH)D. It was found that 83% of men have severe vitamin D deficiency with a median of 19.40 ng/ml and 82.8% of women, with a median of 19.80 ng/ml. The most vulnerable age groups with low vitamin D supply in men are early childhood and young age from 19 to 22 years. In the female population, the lowest values of 25(OH)D (18.84 ng/ml) are observed in old age.

Keywords:vitamin D deficiency, children, adults, men, women

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Conclusion. Concept and design development, discussion ofthe manuscript and content verification, final approval for the publication of the manuscript - Kondratyeva E.I.; final approval for the publication of the manuscript - Zakharova I.N.; statistical processing, preparation and structuring of the article material, analysis and interpretation of data - Loshkova E.V.; advisory assistance, verification of critical intellectual content; organization of laboratory research, analysis and interpretation of data - Shubina Yu.F.; advice, discussion and interpretation of data - Odinaeva N.D.; laboratory research, analysis and interpretation of data - Melianovskaya Yu.L.; laboratory research, analysis and interpretation of data - Zodbinova A.E.

For citation: Kondratyeva E.I., Loshkova E.V., Zakharova I.N., Saprina T.V., Shubina Yu.F., Nikonova V.S., Melyanovskaya Yu.L., Zodbinova A.E., Odinaeva N.D. Vitamin D deficiency: gender characteristics. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2021; 10 (2): 18-25. DOI: https://doi.org/10.33029/2304-9529-2021-10-2-18-25 (in Russian)

REFERENCES

1. National program «Vitamin D deficiency in children and adolescents of the Russian Federation: modern approaches to correction». In: Union of Pediatricians of Russia et al. Moscow: Pediatr, 2018: 96 p. (in Russian)

2. Pigarova E.A., Rozhinskaya L. Ya., Belaya Zh.E., et al. Clinical guidelines of the Russian Association of Endocrinologists for the diagnosis, treatment and prevention of vitamin D deficiency in adults. Problemy en-dokrinologii [Problems of Endocrinology]. 2016; 62 (4): 60-84. (in Russian)

3. Petrushkina A.A., Pigarova E.A., Rozhinskaya L. Ya. The prevalence of vitamin D deficiency in Russian Federation. Osteoporoz i osteopatii [Osteoporosis and Osteopathy]. 2018; 21 (3): 15-20. DOI: https://doi.org/10.14341/osteo10038 (in Russian)

4. Amrein K., Scherkl M., Hoffmann M., et al. Vitamin D deficiency 2.0: an update on the current status worldwide. Eur J Clin Nutr. 2020; 74: 1498-513. DOI: https://doi.org/10.1038/s41430-020-0558-y

5. Rinonapoli G., Ruggiero C., Meccariello L., Bisaccia M., Ceccarini P., Car-affa A. Osteoporosis in men: a review of an underestimated bone condition. Int J Mol Sci. 2021; 22 (4): 2105. DOI: https://doi.org/10.3390/ijms22042105 PMID: 33672656; PMCID: PMC 7924179.

6. Crowe F.L., Jolly K., MacArthur C., Manaseki-Holland S., Gittoes N., Hewison M., et al. Trends in the incidence of testing for vitamin D deficiency in primary care in the UK: a retrospective analysis of The Health Improvement Network (THIN), 2005-2015. BMJ Open. 2019; 9 (6): e028355.

7. Martucci G., Tuzzolino F., Arcadipane A., Pieber T.R., Schnedl C., Urbanic Purkart T., et al. The effect of high-dose cholecalciferolon bioavailable vitamin D levels in critically ill patients: a post hoc analysis of the VITdAL-ICU trial. Intensive Care Med. 2017; 43: 1732-4. DOI: https://doi.org/10.1007/s00134-017-4846-5

8. Cashman K.D., Dowling K.G., Skrabakova Z., Gonzalez-Gross M., Valtuena J., De Henauw S., et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016; 103: 1033-44. DOI: https://doi.org/10.3945/ajcn.115.120873

9. Grant W.B., Boucher B.J. Why secondary analyses in vitamin d clinical trials are important and how to improve vitamin d clinical trial outcome analyses - a comment on «Extra-Skeletal Effects of Vitamin D, Nutrients. 2019, 11, 1460». Nutrients. 2019; 11: 2182.

10. Manson J.E., Cook N.R., Lee I.M., Christen W., Bassuk S.S., Mora S., et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med. 2018; 380: 33-44. DOI: https://doi.org/10.1056/NE-JMoa1809944

11. Pittas A.G., Dawson-Hughes B., Sheehan P., Ware J.H., Knowler W.C., Aroda V.R., et al. Vitamin D supplementation and prevention of type 2 diabetes. N Engl J Med. 2019; 381: 520-30. DOI: https://doi.org/10.1056/NE-JMoa1900906

12. Zhang Y., Fang F., Tang J., Jia L., Feng Y., Xu P., et al. Association between vitamin D supplementation and mortality: systematic review and meta-analysis. BMJ. 2019; 366: I4673. DOI: https://doi.org/10.1136/bmj.14673

13. Amrein K., Martucci G., McNally J.D. When not to use meta-analysis: analysing the meta-analyses on vitamin D in critical care. Clin Nutr. 2017;36: 1729-30. DOI: https://doi.org/10.1016/j.clnu.2017.08.009

14. Babenko A. Yu., Laevskaya M. Yu. Osteoporosis. Gender characteristics of prevention and treatment. RMZh [Russian Medical Journal]. 2017; (22): 1646-50. (in Russian)

15. Lesnyak O.M. Topical issues of diagnosis and treatment of osteoporosis in men in outpatient practice. Rossiyskiy semeyniy vrach [Russian Family Doctor]. 2017; 21 (1) 39-44. (in Russian)

16. Curtis E.M., et al. Epidemiology of fractures in the United Kingdom 1988-2012: variation with age, sex, geography, ethnicity and socioeconomic status. Bone. 2016; 87: 19-26.

17. Willson T., Nelson S.D., Newbold J., Nelson R.E., LaFleur J. The clinical epidemiology of male osteoporosis: a review of the recent literature. Clin Epidemiol. 2015; 7: 65-76. DOI: https://doi.org/10.2147/CLERS 40966 PMID: 25657593; PMCID: PMC 4295898.

18. Bouillon R., Carmeliet G., Lieben L., Watanabe M., Perino A., Auwerx J., et al. Vitamin D and energy homeostasis: of mice and men. Nat Rev Endocrinol. 2014; 10: 79-87. DOI: https://doi.org/10.1038/nrendo.2013.226

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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