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2 . 2021

Multiple endocrine neoplasia type 1 syndrome: causal factors that make timely diagnosis difficult

Abstract

Multiple endocrine neoplasia syndrome of the first type (MEN-1) is a genetically determined disease with an autosomal dominant type of inheritance, characterized by a tumor lesion of the parathyroid glands, pancreas and anterior pituitary gland. Skin manifestations in the form of neoplasms - lipomas, facial angiofibromas, collagenomas, which are formed before the manifestation of the clinical symptoms of the disease, can serve as harbingers of the MEN-1 syndrome. The peculiarity of the clinical case is an additional atypically located adenoma of the lower parathyroid glands (retrosternal space), detected six years after the onset of the disease.

Keywords:multiple neoplasia type 1 syndrome, papillary thyroid cancer, glucagonoma, parathyroid adenoma

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Kondratyeva L.V., Vovk P.S. Multiple endocrine neoplasia type 1 syndrome: causal factors that make timely diagnosis difficult. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2021; 10 (2): 118-22. DOI: https://doi.org/10.33029/2304-9529-2021-10-2-118-122 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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