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2 . 2021

Markers of inflammatory response and blood coagulation disorders in patients with type 2 diabetes and COVID‑19

Abstract

This study compared coagulation dysfunction and inflammatory status between diabetic and non-diabetic patients with COVID-19 pneumonia. The levels of C-reactive protein were higher in patients with type 2 diabetes, regardless of the severity of pneumonia on CT, but this difference did not reach statistical significance. Patients with type 2 diabetes and COVID-19 pneumonia with minimal changes on CT (CT-1) had higher D-dimer concentrations and lower prothrombin levels (p<0.05). There was no significant difference in coagulation dysfunction in patients with type 2 diabetes and without it. According to the correlation analysis, the mortality rate of patients with COVID-19 and type 2 diabetes was higher than in the general population, but in most cases the prognosis of the disease was not influenced by the isolated presence of type 2 diabetes, but by the comorbidities, calculated with the Charlson comorbidity index.

Keywords:type 2 diabetes mellitus, COVID-19, hypercoagulability, C-reactive protein, comorbidity

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Plakhotnyaya V.M., Demidova T.Yu., Gritskevich E.Yu. Markers of inflammatory response and blood coagulation disorders in patients with type 2 diabetes and COVID-19. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2021; 10 (2): 150-2. DOI: https://doi.org/10.33029/2304-9529-2021-10-2-150-152 (in Russian)

References

1. Apicella M., Campopiano M.C., Mantuano M., et al. COVID-19 in people with diabetes: understanding the reasons for worse outcomes. Lancet. 2020; 8 (9): 782-92.

2. Lim S., Bae J.H., Kwon H.S., et al. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 2021; 17: 11-30.

3. Varikasuvu S.R., Varshney S., Dutt N. Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19. J Thromb Thrombolysis. 2021; 51: 941-6.

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All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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