Markers of inflammatory response and blood coagulation disorders in patients with type 2 diabetes and COVID‑19
AbstractThis study compared coagulation dysfunction and inflammatory status between diabetic and non-diabetic patients with COVID-19 pneumonia. The levels of C-reactive protein were higher in patients with type 2 diabetes, regardless of the severity of pneumonia on CT, but this difference did not reach statistical significance. Patients with type 2 diabetes and COVID-19 pneumonia with minimal changes on CT (CT-1) had higher D-dimer concentrations and lower prothrombin levels (p<0.05). There was no significant difference in coagulation dysfunction in patients with type 2 diabetes and without it. According to the correlation analysis, the mortality rate of patients with COVID-19 and type 2 diabetes was higher than in the general population, but in most cases the prognosis of the disease was not influenced by the isolated presence of type 2 diabetes, but by the comorbidities, calculated with the Charlson comorbidity index.
Keywords:type 2 diabetes mellitus, COVID-19, hypercoagulability, C-reactive protein, comorbidity
Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
For citation: Plakhotnyaya V.M., Demidova T.Yu., Gritskevich E.Yu. Markers of inflammatory response and blood coagulation disorders in patients with type 2 diabetes and COVID-19. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2021; 10 (2): 150-2. DOI: https://doi.org/10.33029/2304-9529-2021-10-2-150-152 (in Russian)
References
1. Apicella M., Campopiano M.C., Mantuano M., et al. COVID-19 in people with diabetes: understanding the reasons for worse outcomes. Lancet. 2020; 8 (9): 782-92.
2. Lim S., Bae J.H., Kwon H.S., et al. COVID-19 and diabetes mellitus: from pathophysiology to clinical management. Nat Rev Endocrinol. 2021; 17: 11-30.
3. Varikasuvu S.R., Varshney S., Dutt N. Markers of coagulation dysfunction and inflammation in diabetic and non-diabetic COVID-19. J Thromb Thrombolysis. 2021; 51: 941-6.
4. Ng K.E., Rickard J.P. The effect of COVID-19 on patients with diabetes. US Pharm. 2020; 45 (11): 9-12.