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3 . 2021

Disorders of carbohydrate metabolism in patients with pancreatic diseases: features of diagnosis and pathogenesis

Abstract

In the 21st century it is already known that the gradation of diabetes mellitus only into classical types 1 and 2 is impossible, a number of mutations associated with MODY diabetes and other "specific types" have already been discovered. However, a rather large and at the same time poorly studied group consists of patients with disease or surgery on the pancreas. This type of diabetes, developed as a result of pancreatic pathology, belongs to type 3c and hold 8-10% of the entire structure of diabetes mellitus. This article describes in detail what the criteria for diagnosing this type of diabetes are based on and how the interaction of α-, PP, δ- and β-cells of the islets of Langerhans can affect carbohydrate metabolism, including the contribution of malabsorption and incretins.

Keywords:diabetes, islets of Langerhans, pancreas, carbohydrates, β-cells

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Ametov A.S., Shabunin A.V., Pashkova E.Yu., Golodnikov I.I., Gosnevskaya I.V. Disorders of carbohydrate metabolism in patients with pancreatic diseases: features of diagnosis and pathogenesis. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2021; 10 (3): 52-8. DOI: https://doi.org/10.33029/2304-9529-2021-10-3-52-58 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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