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4 . 2021

Men's health after COVID-19 in patients with type 2 diabetes mellitus and hypogonadism

Abstract

Many male patients who have had CoronaVirus Disease 2019 (COVID-19) report the deterioration of general condition. We were interested in the assessment of the onset of symptoms in comparison with the symptom complexes in patients with type 2 diabetes mellitus (T2DM) and hypogonadism.

The aim of the study is to describe the symptom complexes in male patients recovered after COVID-19.

Material and methods. A full-design cross-sectional study was conducted among 100 men who have had moderate COVID-19 with an outpatient care and 2 comparison groups of men with T2DM (n=50) and with hypogonadism (n=50). Participants completed the Aging Males' Symptoms (AMS) scale. Differences between groups were considered statistically significant with p<0.05.

Results. According to the sum of the scores of the AMS scale, the symptoms in each group were moderate. The sum of scores for psychological, sexual, somatic symptoms, as well as the total score for patients with T2DM was statistically significantly lower in men who have had COVID-19. When comparing the results of the scale of patients after COVID-19 and men with hypogonadism, there were statistically significantly higher scores for psychological, somatic symptoms and the total score for men from the COVID-19 group, while statistically significant differences in scores of sexual symptoms were not identified. The sum of scores for psychological, sexual, somatic symptoms, and the total score was statistically significantly lower for vaccinated patients compared with unvaccinated men who have had COVID-19.

Conclusion. Even after the patient's recovery from COVID-19, there are some negative consequences which affect the male health. The symptoms of this disease are similar to the hypogonadism syndrome, but affect the psychological status in a worse way.

Keywords:men, COVID-19, diabetes, hypogonadism

Funding. The research was carried out with support of the Voronezh State Medical University named after N.N. Burdenko of the Ministry of Healthcare of the Russian Federation, from extrabudgetary funds, as well as from personal finances of the authors.

Conflict of interest. The authors declare no conflict of interest.

Contribution. The concept and design of the study, collection and processing of material writing - Esaulenko D.I.; collection and processing of material, writing - E.R. Rozhivanova; data collection - Zakurdaev V.A.; substantial contributions to conception and design of the study, editing - Rozhivanova E.R. All authors approved the final version of the manuscript, agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

For citation: Esaulenko D.I., Rozhivanova E.R., Zakurdaev V.A., Rozhivanov R.V. Men's health after COVID-19 in patients with type 2 diabetes mellitus and hypogonadism. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2021; 10 (4): 25-32. DOI: https://doi.org/10.33029/2304-9529-2021-10-4-25-32 (in Russian)

References

1. Temporary guidelines. Prevention, diagnosis and treatment of new coronavirus infection (COVID-19). Version11 (07.05.21). Ministry of Health of the Russian Federation; 225 p. (in Russian)

2. Li X., et al. Potential of large «first generation» human-to-human transmission of 2019-nCoV. J Med Virol. 2020; 92 (4): 448–54. DOI: https://doi.org/10.1002/jmv.25693

3. World Health Organization. Infection prevention and control guidance for long-term care facilities in the context of COVID-19: interim guidance, 21 March 2020. World Health Organization, 2020.

4. Wambier C.G., Goren A. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is likely to be androgen mediated. J Am Acad Dermatol. 2020; 83 (1): 308-9. DOI: https://doi.org/10.1016/jjaad.2020.04.032

5. Manning J.T., Fink B. Digit ratio, nicotine and alcohol intake and national rates of smoking and alcohol consumption. Pers Individ Differ. 2011; 50 (3): 344-8. DOI: https://doi.org/10.1016/j.paid.2010.10.016

6. Wambier C.G., Goren A., Vaco-Galvan S., et al. Androgen sensitivity gateway to COVID-19 disease severity. Drug Dev Res. 2020; 81 (7): 771-6. DOI: https://doi.org/10.1002/ddr.21688

7. Ayoubkhani D., Khunti K., Nafilyan V., Maddox T., Humberstone B., Diamond I., et al. Post-COVID syndrome in individuals admitted to hospital with covid-19: retrospective cohort study. BMJ. 2021; 372: n693. DOI: https://doi.org/10.1136/bmj.n693 PMID: 33789877; PMCID: PMC 8010267.

8. Heinemann L.A., Saad F., Zimmermann T., et al. The Aging Males’ Symptoms (AMS) scale: update and compilation of international versions. Health Qual Life Outcomes. 2003; 1: 15. DOI: https://doi.org/10.1186/1477-7525-1-15

9. Dedov I.I., Mel’nichenko G.A., Shestakova M.V., Rozhivanov R.V., Terehova A.L., Zilov A.V., et al. Guidelines for the Diagnosis and Treatment of testosterone deficiency (hypogonadism) in male patients with diabetes mellitus. Ozhirenie i metabolizm [Obesity and Metabolism]. 2017; 14 (4): 83-92. DOI: https://doi.org/10.14341/omet2017483-92 (in Russian)

10. Huang C., Huang L., Wang Y., Li X., Ren L., Gu X., et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet. 2021; 397 (10 270): 220-32. DOI: https://doi.org/10.1016/S0140-6736(20)32656-8 Epub 2021 Jan 8. PMID: 33428867; PMCID: PMC 7833295.

11. Sigfrid L., Drake T.M., Pauley E., Jesudason E.C., Olliaro P., Lim W.S., et al.; ISARIC 4C investigators. Long COVID in adults discharged from UK hospitals after COVID-19: a prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. Lancet Reg Health Eur. 2021; Aug 6: 100186. DOI: https://doi.org/10.1016/j.lanepe.2021.100186 Epub ahead of print. PMID: 34386785; PMCID: PMC 8343377.

12. Dedov I.I., Shestakova M.V. Type 2 diabetes mellitus: from theory to practice. Moscow: MIA, 2016: 576 p. (in Russian)

13. Dedov I.I., Shestakova M.V., Mayorov A. Yu., Vikulova O.K., Gal-styan G.R., Kuraeva T.L., et al. Standards of specialized diabetes care. In: I.I. Dedov, M.V. Shestakova, A. Yu. Mayorov (eds). 9th ed. Sakharniy diabet [Diabetes Mellitus]. 2019; 22 (1S 1): 1-144. DOI: https://doi.org/10.14341/DM221S1 (in Russian)

14. Janiri D., Kotzalidis G.D., Giuseppin G., Molinaro M., Modica M., Montanari S., et al.; Gemelli Against COVID-19 Post-Acute Care Study Group. Psychological distress after COVID-19 recovery: reciprocal effects with temperament and emotional dysregulation. an exploratory study of patients over 60 years of age assessed in a post-acute care service. Front Psychiatry. 2020; 11: 590135. DOI: https://doi.org/10.3389/fpsyt.2020.590135 PMID: 33304286; PMCID: PMC 7693440.

15. Rastrelli G., Di Stasi V., Inglese F., Beccaria M., Garuti M., Di Cos-tanzo D., et al. Low testosterone levels predict clinical adverse outcomes in SARS-CoV-2 pneumonia patients. Andrology. 2021; 9 (1): 88-98. DOI: https://doi.org/10.1111/andr.12821 PMID: 32436355

16. Moreno-Perez O., Merino E., Alfayate R., Torregrosa M.E., Andres M., Leon-Ramirez J.M., et al.; COVID 19-ALC Research Group. Male pituitary-gonadal axis dysfunction in post-acute COVID-19 syndrome. Prevalence and associated factors: A Mediterranean Case Series. Clin Endocrinol (Oxf). 2021; Jun 23. DOI: https://doi.org/10.1111/cen.14537 Epub ahead of print. PMID: 34160836.

17. Das L., Dutta P., Walia R., Mukherjee S., Suri V., Puri G.D., et al. Spectrum of endocrine dysfunction and association with disease severity in patients with COVID-19: insights from a cross-sectional, observational study. Front Endocrinol (Lausanne). 2021; 12: 645787. DOI: https://doi.org/10.3389/fendo.2021.645787 PMID: 34276556; PMCID: PMC 8283965.

18. Hodgson S.H., Mansatta K., Mallett G., Harris V., Emary K.R.W., Pollard A.J. What defines an efficacious COVID-19 vaccine? A review of the challenges assessing the clinical efficacy of vaccines against SARS-CoV-2. Lancet Infect Dis. 2021; 21 (2): e26-35. DOI: https://doi.org/10.1016/S1473-3099(20)30773-8 Epub 2020 Oct 27. PMID: 33125914; PMCID: PMC 7837315.

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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