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4 . 2021

Alogloptin and pioglitazone. Perspectives of combined administration

Abstract

The article presents a review on the effect of alogliptin and pioglitazone on different pathogenesis components of type 2 diabetes mellitus. The information about their efficiency both individually and in combination is provided. The hypoglycemic effect of these drugs is implemented via decrease in insulin resistance, improving glucose tolerance and protecting pancreatic p-cells. In addition to hypoglycemic effect, these dipeptidyl peptidase-4 inhibitor and thiazolidinedione agents also have pleiotropic effect concerning cardio-, nephro- and hepatoprotection.

Keywords:diabetes mellitus, hyperglycemia, insulin resistance, dipeptidyl peptidase-4 inhibitors, alogliptin, thiazolidinediones, pioglitazone

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Demidova T.Yu., Kochina A.S. Alogloptin and pioglitazone. Perspectives of combined administration. Endokri-nologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2021; 10 (4): 62-8. DOI: https://doi.org/10.33029/2304-9529-2021-10-4-62-68 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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