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1 . 2022

The ability to block "metabolic memory" in patients with impaired glucose tolerance


The progression of the pathological process of impaired glucose tolerance/or impaired fasting glycemia lasts for many years. However, patients with impaired glucose tolerance (IGT) will move to the category of patients with type 2 diabetes mellitus in certain circumstances. Do doctors have mechanisms that helps to block the "metabolic memory" of the body in real clinical practice and delay the progression of insulin resistance, endothelial dysfunction and vascular complications? The effect of a combination of metformin at a dose of 1700 mg and taurine at a dose of 1000 mg on the level of insulin resistance was evaluated from this angle in 50 patients with new-onset IGT with continuous administration of treatment for 18 months. The assessment was carried out using the coefficient of the ratio of the insulin level at the 120th minute to the level of insulin at the 0th minute (coefficient K1), the data obtained showed a high level of its information value (as an indicator of IGT). Further analysis revealed that with an increase in the insulin level at the 120th minute up to 4 times, glucose metabolism was restored in 100% of cases, and the diagnosis of IGT was withdrawn. With an increase in K1 from 4 to 7.5 times, restoration of glucose metabolism was observed in 61.1% of cases. With an increase in the K1 level by 7.5 times or more, the diagnosis of IGT remained in 71.4% of cases.

Thus, the combination of metformin at a dose of 1700 mg and taurin at a dose of 1000 mg with a change in lifestyle and an increase in exercise allows patients with impaired glucose tolerance to block "metabolic memory". The K1 coefficient discussed in this study has a high predictive ability, which makes it possible to facilitate the doctor to develop therapeutic strategies to reduce the risk of type 2 diabetes mellitus at a outpatient care.

Keywords:impaired glucose tolerance; metformin; taurine; "metabolic memory"; insulin resistance; coefficient of K1

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Manovitskaya A.V., Dubrova T.A. The ability to block «metabolic memory» in patients with impaired glucose tolerance. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (1): 17-23. DOI: (in Russian)


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Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
Конгресс, посвященный Всемирному дню борьбы с ожирением
Эндокринология столицы - Московский городской съезд эндокринологов
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