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2 . 2022

Glucagon-like peptide 1 in patients with type 2 diabetes mellitus on insulin therapy


Insulin administration is one of the ways to intensify glucose-lowering therapy in type 2 diabetes mellitus (T2DM). The postprandial dynamics of glucagon-like peptide‑1 (GLP-1) in patients with different secretory activity of pancreatic β-cells in patients with T2DM has not been adequately studied.

Aim is to evaluate the stimulated secretion of GLP-1 and C-peptide in patients with T2DM on insulin therapy.

Material and methods. In 108 patients with T2DM on insulin therapy, residual insulin secretion was determined by C-peptide. In patients with different secretory activity of β-cells of the pancreas in a test with “standard breakfast” the degree of changes in C-peptide and GLP-1 at 30 min point was measured, the results were compared with those of healthy individuals.

Results. The basal level of GLP-1 in patients with T2DM was lower than in healthy individuals and was not associated with the basal level of C-peptide. The increase in the level of GLP-1 after standard breakfast in patients with T2DM and signs of secretory deficiency (C-peptide <1.1 ng/ml) was significantly higher than in patients with an increased basal level of C-peptide (>4.4 ng/ml) (p<0.001).

Keywords:type 2 diabetes mellitus; insulin therapy; C-peptide; glucagon-like peptide 1

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Lisker A.V., Semikova G.V., Volkova A.R. Glucagon-like peptide‑1 in patients with type 2 diabetes mellitus on insulin therapy. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (2): 9–13. DOI: (in Russian)


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Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
Medicine today

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