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2 . 2022

Arterial hypertension associated with physiological hyperandrogenism in men


It has been established that the problem of arterial hypertension is noted more often among transgender men than in the general population. In addition, an increase of blood pressure is often observed in men using androgenic anabolic steroids. In this regard, the assessment of arterial hypertension in men with physiological hyperandrogenism is relevant.

Aim – ​to assess the presence of correlation between arterial hypertension and physiological hyperandrogenism in men.

Material and methods. A continuous cross-sectional study of 80 men with hyperandrogenism. During the study, the levels of luteinizing hormone, total testosterone, sex hormone-binding globulin were determined with further calculation of free testosterone according to Vermeulen equation and dihydrotestosterone (DHT). In men with elevated testosterone levels estradiol was determined. Blood pressure was monitored by measuring it with a tonometer 3 times a day for 2 weeks. Differences between groups were considered statistically significant at p<0.05.

Results. Morning blood pressure was statistically significantly higher in men with elevated total and free testosterone compared to men with elevated DHT. An increase in blood pressure was characteristic for 35% of patients with elevated levels of total and free testosterone. Statistically significant differences were found between patients with and without arterial hypertension in the level of estradiol, which, while remaining within the normal range, was lower in the group of patients with arterial hypertension.

Conclusion. Physiological hyperandrogenism, accompanied by an increased testosterone levels, may be associated with arterial hypertension. Estrogen production may be a factor influencing its development.

Keywords:hyperandrogenism; testosterone; dihydrotestosterone; men; arterial hypertension

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Data collection, analysis and interpretation of the results, text writing – ​Filatova V.A.; the concept and design of the study, editing a manuscript in order to increase scientific value of the article – ​Rozhivanov R.V. All authors approved the final version of the article before publication, agreed to be responsible for all aspects of the work, implying the proper study and resolution of issues related to the accuracy or integrity of any part of it.

For citation: Filatova V.A., Rozhivanov R.V. Arterial hypertension associated with physiological hyperandrogenism in men. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (2): 41–6. DOI: (in Russian)


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Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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