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2 . 2022

Pathogenetic therapy of diabetic polyneuropathy


The aim of the study was to evaluate the effectiveness of alpha-lipoic acid (ALA) course therapy for diabetic polyneuropathy in patients with type 2 diabetes mellitus (T2DM).

Material and methods. The study involved 31 patients aged 51–70 years with a diagnosis of T2DM with distal sensorimotor diabetic polyneuropathy. The patients were prescribed course therapy with ALA 600 mg intravenously for 10 days (10 infusions) with a 6-month interval.

Results and discussion. At the start of the study, a decrease in the level of antioxidant enzymes was observed in 1/4 of the patients. A statistically significant decrease in the clinical manifestations of diabetic polyneuropathy according to the TSS and NIS-LL scales was observed against the background of course treatment of DPN with ALA (p<0.05). There was also an improvement in electrophysiological parameters of sensory and motor nerves of lower extremities. The use of ALA contributed to a statistically significant increase in level of antioxidant enzyme GPO (p<0.05).

Conclusion. Course treatment of DPN with ALA helps to increase level of antioxidant enzymes, reduce clinical manifestations of DPN and normalize electrophysiological parameters of sensory and motor nerves of lower extremities.

Keywords:diabetic polyneuropathy; pathogenetic therapy of diabetic polyneuropathy; alpha-lipoic acid; thioctacid; antioxidant enzymes

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Ametov A.S., Kosyan A.A., Strokov I.A. Pathogenetic therapy of diabetic polyneuropathy. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (2): 47–55. DOI: (in Russian)


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Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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