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2 . 2022

Benefits for pioglitazone in prevention and treatment of type 2 diabetes mellitus and its complications


The article reflects the main ideas about the effects of the thiazolidinediones group drug pioglitazone, its place in the modern view on the treatment of type 2 diabetes mellitus. The possibilities of its combination with alogliptin, the inhibitors of dipeptidyl peptidase 4 group drug, as well as the advantages of using a fixed combination of the drug, are highlighted. These groups of drugs have different points of application of action, which enhances the hypoglycemic effect without the risk of hypoglycemia.

Keywords:thiazolidinediones; pioglitazone; inhibitors of dipeptidyl peptidase 4; alogliptin; type 2 diabetes mellitus; combination therapy

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Ametov А.S., Pyanykh O.P., Vovk P.S. Benefits for pioglitazone in prevention and treatment of type 2 diabetes mellitus and its complications. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (2): 56–63. DOI: (in Russian)


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Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
Medicine today

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