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2 . 2022

Problems of diagnosis and treatment of acromegaly

Abstract

The review discusses current problems of diagnosis and multidisciplinary treatment of acromegaly. The reasons contributing to the delayed detection of the disease, increased comorbidity and the formation of the status of a difficult patient with limited therapeutic maneuver capabilities are analyzed. The modern possibilities of patient- and tumor-oriented diagnosis of acromegaly, the most effective methods of primary and adjuvant therapy, as well as issues of correction of postoperative complications are covered in detail. Particular attention is paid to the topic of differentiated treatment of acromegaly syndrome, taking into account the presence of multiple pathomorphological variants of somatotroph adenomas, differing in clinical, biochemical, radiological and therapeutic characteristics. The paper emphasizes the need for further improvement of personalized predictive programs that allow predicting the course of the disease and the effectiveness of the proposed pharmacotherapy. The importance of lifelong dynamic monitoring of all patients for the purpose of operative correction of the treatment regimen and timely detection of progressive growth of a residual tumor and possible relapse is substantiated.

Keywords:acromegaly; laboratory and instrumental diagnostics; surgical and medical treatment

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Pronin V.S., Astafyeva L.I. Problems of diagnosis and treatment of acromegaly. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (2): 71–82. DOI: https://doi.org/10.33029/2304-9529-2022-11-2-71-82 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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