To the content
2 . 2022

Post-transplant diabetes mellitus after kidney transplantation: its special aspects and our potentiality

Abstract

One of the common complications after kidney transplantation is post-transplant diabetes mellitus. Until now, there is no strictly algorithm for the management of glycemia in patients after transplantation in the world. Carbohydrate metabolism disorder in this patient cohort has special characteristics due to the use of immunosuppressive therapy. Since post-transplant survival has increased, advanced research activities are determining the efficacy and safety of new classes of antidiabetic drugs in kidney transplant recipients.

Keywords:post-transplant diabetes mellitus; cardiovascular events; immunosuppressive therapy; antidiabetic drugs

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Mitchenko Yu.I., Drozdov P.A., Ametov A.S. Post-transplant diabetes mellitus after kidney transplantation: its special aspects and our potentiality. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (2): 83–7. DOI: https://doi.org/10.33029/2304-9529-2022-11-2-83-87 (in Russian)

REFERENCES

1. Wang J.H., Skeans M.A., Israni A.K. Current status of kidney transplant outcomes: dying to survive. Adv Chronic Kidney Dis. 2016; 23 (5): 281–6. DOI: https://doi.org/10.1053/j.ackd.2016.07.001; PMID: 27742381.

2. Sultanov P.K., Hadzhibaev F.A., Ergashev D.N., Ismatov A.A. Analysis of complications after kidney transplantation: literature review. Vestnik ekstrennoy meditsiny [Bulletin of Emergency Medicine]. 2021; 14 (1): 55–64. (in Russian)

3. Gautier S.V., Khomyakov S.V. Organ donation and transplantation in the Russian Federation in 2019. 12th report on register of the Russian Transplant Society. Vestnik transplantologii i iskusstvennykh organov [Bulletin of Transplantology and Artificial Organs]. 2020; 22 (2): 8–34. DOI: https://doi.org/10.15825/1995-1191-2020-2-8-34 (in Russian)

4. Clinical practice guideline «Kidney transplantation, presence of a transplanted kidney, death and rejection of a kidney transplant», developed by «Russian Transplantological Society». 2020. (in Russian)

5. Lin H., Yan J., Yuan L., et al. Impact of diabetes mellitus developing after kidney transplantation on patient mortality and graft survival: a meta-analysis of adjusted data. Diabetol Metab Syndr. 2021; 13: 126. DOI: https://doi.org/10.1186/s13098-021-00742-4

6. Martirosyan S.M., Kosmacheva E.D. Prevalence of cardiovascular disease before and after kidney transplantation. Al’manakh klinicheskoy meditsiny [Almanac of Clinical Medicine]. 2017; 45 (7): 575–85. DOI: https://doi.org/10.18786/2072-0505-2017-45-7-575-585 (in Russian)

7. Sharif A., Hecking M., de Vries A.P., et al. Proceedings from an international consensus meeting on posttransplantation diabetes mellitus: recommendations and future directions. Am J Transplant. 2014; 14 (9): 1992–2000. DOI: https://doi.org/10.1111/ajt.12850; PMID: 25307034.

8. Dong M., Parsaik A.K., Eberhardt N.L., et al. Cellular and physiological mechanisms of new-onset diabetes mellitus after solid organ transplantation. Diabet Med. 2012; 29 (7): 1–12.

9. Dai C., Walker J.T., Shostak A., et al. Tacrolimus- and sirolimus-induced human β cell dysfunction is reversible and preventable. JCI Insight. 2020; 5 (1): e130770. DOI: https://doi.org/10.1172/jci.insight.130770

10. Balashova A.V., Mustafina V.R., Glinkina I.V. Interdisciplinary problem of post-transplant diabetes mellitus: literature review. Sechenovskiy vestnik [Sechenov Bulletin]. 2021; 12 (1): 60–73. DOI: https://doi.org/10.47093/2218-7332.2021.12.1.60-73 (in Russian)

11. KDIGO 2020 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease. Transl. A. Denisov, ed. E. Zakharova. Nefrologiya i dializ. Prilozhenie [Nephrology and Dialysis. Supplement]. 2021; 23 (2): 9–121. DOI: https://doi.org/10.28996/2618-9801-2021-2suppl-9-121 (in Russian)

12. Montada-Atin T., Prasad G.V.R. Recent advances in new-onset diabetes mellitus after kidney transplantation. World J Diabetes. 2021; 12 (5): 541–55. DOI: https://doi.org/10.4239/wjd.v12.i5.541

13. Antsiferov M.B., Koteshkova O.M., Novikova M.S., Demidov N.A. Possibilities of dapagliflozin in cardio-renometabolic protections in patients with and without type 2 diabetes mellitus. Farmateka [Pharmateca]. 2021; 28 (12): 53–9. (in Russian)

14. Schwaiger E., Burghart L., Signorini L., et al. Empagliflozin in posttransplantation diabetes mellitus: a prospective, interventional pilot study on glucose metabolism, fluid volume, and patient safety. Am J Transplant. 2019; 19: 907–19. DOI: https://doi.org/10.1111/ajt.15223

15. Hecking M., Sharif A., Eller K., Jenssen T. Management of post-transplant diabetes: immunosuppression, early prevention, and novel antidiabetics. Transplant Int. 2021; 34 (1): 27–48. DOI: https://doi.org/10.1111/tri.13783

16. Kanbay M., Demiray A., Afsar B., et al. Sodium-glucose cotransporter 2 inhibitors for diabetes mellitus control after kidney transplantation: review of the current evidence. Nephrology. 2021; 26 (12): 1007–17. DOI: https://doi.org/10.1111/nep.13941

CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
Вскрытие
Medicine today

Уважаемые коллеги, до XI-го Национального конгресса с международным участием имени Н.О. Миланова "Пластическая хирургия, эстетическая медицина и косметология" осталось 3 дня! С 29 ноября по 1 декабря 2022 года в Москве пройдет XI Национальный конгресс "Пластическая хирургия,...

6-7 декабря 2022 года состоится юбилейная X конференция с международным участием "Креативная кардиология и кардиохирургия. Новые технологии диагностики и лечения заболеваний сердца", которая будет проходить в очном и онлайн-формате в ФГБУ "НМИЦ ССХ им. А.Н. Бакулева"...

Приглашаем 1 и 2 декабря в Москву на яркий профессиональный праздник - итоговую всероссийскую Школу РОАГ! Школа в Москве занимает особое место в образовательном цикле Школ РОАГ. На ней подводятся итоги прошедшего сезона, обсуждаются темы, которые вызывают наибольший интерес...


Journals of «GEOTAR-Media»