The role of insulin resistance and pancreatic β-cell dysfunction in development of prediabetes in obese adolescents
AbstractObesity is one of the main risk factors for developing type 2 diabetes mellitus. The pathophysiology of type 2 diabetes mellitus is based on defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Young people have a more aggressive course of the disease. However, the impact and sequence of pathological mechanisms involved in the development of type 2 diabetes mellitus in adolescents hasn’t been established. This research examined the role of pancreatic β-cell dysfunction and insulin resistance in the development of prediabetes in obese adolescents. This study included 95 obese adolescents (mean age 14.4±1.63 years; boys, n=55). Despite the fact that both groups had the equal level of insulin resistance, the impairment of β-cell function in prediabetics and nonprediabetics was too dissimilar. Hence, β-cell defect can be the main driving mechanism in youth-onset prediabetes and an unfavorable prognostic factor. Diagnosis of prediabetes can help preventing of the development of type 2 diabetes mellitus.
Keywords:prediabetes; insulin resistance; HOMA; β-cell dysfunction; obesity
Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
For citation: Minkova N.B., Romaykina D.S. The role of insulin resistance and pancreatic β-cell dysfunction in development of prediabetes in obese adolescents. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (3): 105–7. DOI: https://doi.org/10.33029/2304-9529-2022-11-3-105-107 (in Russian)