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3 . 2022

The role of insulin resistance and pancreatic β-cell dysfunction in development of prediabetes in obese adolescents

Abstract

Obesity is one of the main risk factors for developing type 2 diabetes mellitus. The pathophysiology of type 2 diabetes mellitus is based on defective insulin secretion by pancreatic β-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Young people have a more aggressive course of the disease. However, the impact and sequence of pathological mechanisms involved in the development of type 2 diabetes mellitus in adolescents hasn’t been established. This research examined the role of pancreatic β-cell dysfunction and insulin resistance in the development of prediabetes in obese adolescents. This study included 95 obese adolescents (mean age 14.4±1.63 years; boys, n=55). Despite the fact that both groups had the equal level of insulin resistance, the impairment of β-cell function in prediabetics and nonprediabetics was too dissimilar. Hence, β-cell defect can be the main driving mechanism in youth-onset prediabetes and an unfavorable prognostic factor. Diagnosis of prediabetes can help preventing of the development of type 2 diabetes mellitus.

Keywords:prediabetes; insulin resistance; HOMA; β-cell dysfunction; obesity

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Minkova N.B., Romaykina D.S. The role of insulin resistance and pancreatic β-cell dysfunction in development of prediabetes in obese adolescents. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (3): 105–7. DOI: https://doi.org/10.33029/2304-9529-2022-11-3-105-107 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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