Effect of antioxidant enzyme levels on the severity of diabetic polyneuropathy
The article discusses the effect of the level of antioxidant enzymes on the severity of diabetic polyneuropathy in patients with type 2 diabetes mellitus. As a result, it was shown that a decrease in the level of superoxide dismutase leads to an increase in neurological symptoms according to the TSS scale (Total Symptoms Score) and neuropathic disorders of the lower extremities according to the NIS-LL scale (Neuropathy Impairment Scoreinthe Lower Limbs).
Keywords:type 2 diabetes mellitus; diabetic polyneuropathy; superoxide dismutase; antioxidant system
Funding. The study had no sponsor support.
Conflict of interest. The author declares no conflict of interest.
For citation: Kosyan A.A. Effect of antioxidant enzyme levels on the severity of diabetic polyneuropathy. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2022; 11 (3): 113–5. DOI: https://doi.org/10.33029/2304-9529-2022-11-3-113-115 (in Russian)
- Global report on diabetes of WHO. 2016.
- Tesfaye S., Boulton A.J., Dickenson A.H. Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care. 2013; 36 (9): 2456-65.
- Ametov A.S., Alimova G.U. Diabetes mellitus and oxidative stress. Эндокринология: новости, мнения, обучение. 2014. № 1. С. 47-50.
- Ametov A.S., Kosyan A.A. The role and point of the disturbed redox balance in the development of diabetic neuropathy and antioxidant effects of alpha-lipoic acid. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2020; 9 (2): 70-9. (in Russian)