To the content
3 . 2023

Cytokine status in patients with ST-segment elevation myocardial infarction and carbohydrate metabolism disorders

Abstract

The paper is dedicated to the study of the nature of the inflammatory response in patients with acute ST-segment elevation myocardial infarction (STEMI) and type 2 diabetes mellitus (T2DM), impaired glucose tolerance/impaired fasting glycemia (IGT/IFG). Analysis of the results showed a marked increase in the levels of interleukin‑1β, interleukin‑6, and interleukin‑10 in patients with both T2DM and STEMI, as well as IGT/IFG and STEMI relative to the control group.

Keywords:diabetes mellitus; myocardial infarction; inflammation; cytokines

Funding. The study had no sponsor support.

Conflict of interest. The author declares no conflict of interest.

For citation: Tsyretorova S.S. Cytokine status in patients with ST-segment elevation myocardial infarction and carbohydrate metabolism disorders. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2023; 12 (3): 77–8. (in Russian)

DOI: https://doi.org/10.33029/2304-9529-2023-12-3-77-78 (in Russian)

References

1. International Diabetes Federation. IDF Diabetes Atlas. 10th ed. 2021.

2. Dedov I.I., Shestakova M.V., Vikulova O.K., et al. Epidemiological characteristics of diabetes mellitus in the Russian Federation: clinical and statistical analysis according to the Federal diabetes register data of 01.01.2021. Sakharni diabet [Diabetes Mellitus]. 2021; 24 (3): 204–21. (in Russian)

3. Laichuthai N., Abdul-Ghani M., Kosiborod M., et al. Newly discovered abnormal glucose tolerance in patients with acute myocardial infarction and cardiovascular outcomes: a meta-analysis. Diabetes Care. 2020; 8: 1958–66.

4. Lee J., Lee S., Zhang H., Hill M.A., et al. Interaction of IL‑6 and TNF-α contributes to endothelial dysfunction in type 2 diabetic mouse hearts. PLoS One. 2017; 12 (11): 0187189.

5. Kalinskaya A., Dukhin O., Lebedeva A., et al. Circulating cytokines in myocardial infarction are associated with coronary blood flow. Front Immunol. 2022; 13: 837642.

All articles in our journal are distributed under the Creative Commons Attribution 4.0 International License (CC BY 4.0 license)

CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
Вскрытие

Journals of «GEOTAR-Media»