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4 . 2023

Role and place of dulaglutide in type 2 diabetes mellitus management

Abstract

Destructive macro- and microvascular complications of diabetes mellitus lead to an increase of mortality, loss of vision, kidney failure and a an overalldecrease in quality of life. The appearance of GLP-1 receptor agonists (GLP-1 RAs) has become a breakthrough in the treatment of patients with type 2 diabetes. The multidirectional pleiotropic effects of GLP-1 RAs make it possible to classify them as disease-modifying drugs in the treatment of type 2 diabetes. Dulaglutide is an effective and easy-to-use hypoglycemic drug that leads to a pronounced and sustained weight loss and has a cardioprotective effect, contributing to both secondary and primary prevention of cardiovascular diseases.

Keywords:type 2 diabetes mellitus; dulaglutide; antidiabetic effect; cardioprotective effect; ease of use; patient profile

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

Contribution. Thematic publications reviewing, writing of the article, data processing, analysis and interpretation, approval of the manuscript for publication – Ametov A.S., Pyanykh O.P.; writing the text and design of the article, thematic publications reviewing – Antsiferova D.M.

For citation: Ametov A.S., Antsiferova D.M., Pyanykh O.P. Role and place of dulaglutide in type 2 diabetes mellitus management. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2023; 12 (4): 72–7. DOI: https://doi.org/10.33029/2304-9529-2023-12-4-72-77 (in Russian)

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CHIEF EDITOR
CHIEF EDITOR
Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
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