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1 . 2024

Flash glucose monitoring in the diagnosis of insulinoma


Insulinoma is a rare pancreatic neuroendocrine tumor, manifested by hypersecretion of insulin. The frequency of occurrence does not exceed 1–3 cases per million per year. Many cases remain undiagnosed due to unexpressed clinical manifestations. In most patients, symptoms appear within 12–18 months after the appearance of the neoplasm, but can slowly progress for decades before a correct diagnosis is made. Basically, erroneous neurological or psychiatric diagnoses are initially established. Continuous flash glucose monitoring can significantly simplify this process and increase the accuracy of measurements, since continuous monitoring of glucose levels in interstitial fluid is carried out, allowing automatic measurement and real-time monitoring of its level. The relevance of flash glucose monitoring for the diagnosis and treatment of insulinoma is based on the need for constant and accurate monitoring of glycemic levels. With insulinoma, the patient has no sensitivity to the level of glycemia, and the autonomous secretion of insulin continues regardless of blood glucose levels. In such cases, continuous flash glucose monitoring helps to prevent hypoglycemic conditions in time and take appropriate measures. The paper presents a clinical case of a long-term course of insulinoma in the absence of timely diagnosis. In questionable situations, the use of flash glucose monitoring is recommended, which may be a priority method for detecting hypoglycemia in diseases associated with hyperinsulinism.

Keywords:insulinoma; flash glucose monitoring

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Morgunov L.Yu., Pokrovsky K.A., Kosimov O.U. Flash glucose monitoring in the diagnosis of insulinoma. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2024; 13 (1): 90–5. DOI: (in Russian)


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Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)

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