Management of patients with metabolic-associated fatty liver disease: an endocrinologist’s view
AbstractThe metabolic syndrome, emerging as a consequence of the steadily increasing obesity pandemic, resulted in a substantial increase in the prevalence of metabolic-associated fatty liver disease (MAFLD) and type 2 diabetes mellitus (T2DM). Insulin resistance (IR) is associated with both the pathogenesis of MAFLD and its progression from steatosis to steatohepatitis, cirrhosis and even hepatocellular carcinoma, which is known to be the leading developmental mechanisms of T2DM. In addition, MAFLD exacerbates or induces IR, impairs glycemic control, and increases the risk of the development of the cardiovascular complications. To date, awareness of this antibiosis is often overlooked by both gastroenterologists and endocrinologists. The tactics of management of such patients should be complex and include the principle of interdisciplinary approach. This review discusses the peculiarities of the pathogenesis of MAFLD and T2DM, diagnostic criteria and perspectives of therapy of MAFLD, including the use of ademetionine.
Keywords: metabolic-associated fatty liver disease; insulin resistance; type 2 diabetes mellitus; obesity; hepatoprotectors; ademetionine
Funding. The study had no sponsor support.
Conflict of interest. The authors declare no conflict of interest.
For citation: Ametov A.S., Amikishieva K.A., Gurieva I.V. Management of patients with metabolic-associated fatty liver disease: an endocrinologist’s view. Endokrinologiya: novosti, mneniya, obuchenie [Endocrinology: News, Opinions, Training]. 2024; 13 (2): 35–46. DOI: https://doi.org/10.33029/2304-9529-2024-13-2-35-46 (in Russian)
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