New feature of modern basal insulin therapy in the treatment of patients with diabetes mellitus type 1 and type 2 from the results of clinical trials to real clinical practice
Abstract
It should be emphasized that among the existing methods of treatment of diabetes mellitus insulin therapy is of particular importance. long duration type 2 diabetes with persistent hyperglycemia lead to decline products β-cell insulin, thus signaling the development of
Prosthetic gene networks as an alternative to standard pharmacotherapies for metabolic disorders
Abstract
Synthetic biology makes inroads into clinical therapy with the debut of closed-loop prosthetic gene networks specifically designed to treat human diseases. Prosthetic networks are synthetic sensor/effector devices that could functionally integrate and interface with host
Effect of increase in prolactin levels on the development of hyperplastic processes of the mammary glands and the possibility of their drug correction
Abstract
A central hypothalamic-pituitary dysfunction of reproductive regulation system is caused by high levels of prolactin in blood serum. 25-30% of menstrual cycle and generative dysfunctions are results of hyperprolactinemia. Higher than normal levels of prolactin cause
Nonalcoholic fatty liver disease and type 2 diabetes: the modern aspects of diagnosis and treatment
Abstract
This article provides analysis of modern data about clinical aspects of diagnosis and treatment of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes, data on the effectiveness of metabolic therapy NAFLD with taurine. Antioxidant, metabolic and
Prognostic value of obesity and adiponectin levels in patients with chronic and treatment
Abstract
This review presents data about prognostic value of obesity in patients with chronic heart failure. The review describes the results of the latest studies about trophological status and adipokines and its' effect on progress and prognosis of heart failure different genesis.
Diabetes mellitus and primary hypothyroidism. Comorbidity aspects
Abstract
The review presents modern data publications of domestic and foreign authors on the problem of combined endocrine pathology - diabetes mellitus and primary hypothyroidism. In most studies, it is noted that hypothyroidism, both overt and subclinical, has an additional
Protein prenylation in islet β-cell function in health and diabetes: putting the pieces of the puzzle together
Abstract
Post-translational prenylation involves incorporation of 15-(farnesyl) or 20-(geranylgeranyl) carbon derivatives of mevalonic acid into highly conserved C-terminal cysteines of proteins. The farnesyl transferase (FTase) and the geranylgeranyl transferase (GGTase) mediate
The modern opinion on the optimisation of the type 2 diabetes mellitus management as the specialized
medical food is used
Abstract
The review presents the modern aspects of the use of the specialized medical nutrition (SMN) for the type 2 diabetes mellitus management. It was demonstrated that SMN is the most effective for the elimination of the postprandial hyperglycemia and high glycemic variability,
The positive metabolic and antioxidative properties of the testosterone replacement therapy at the combination of the type 2 diabetes mellitus and the hypogonadism
Abstract
The treatment of type 2 diabetes mellitus (T2DM) is multifactorial because the complex metabolic targets. The recent approach to T2DM management is associated with the male hypogonadism correction using the testosterone replacement treatment (TRT), the hormone with metabolic
Structural and functional heart remodeling in diabetes mellitus: clinical and instrumental evaluation
Abstract
The purpose of the study - the study of the structural and functional remodeling of the heart in patients with diabetes mellitus type 2 in assessing the risk of cardiovascular complications. Hypertrophy and remodeling of the left ventricle with segmental structural failures