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High-protein low-calorie diet with inclusion of protein meal replacements as an effective strategy for improving condition of patients with overweight, obesity and metabolic syndrome
Abstract
The review presents data from comparative randomized clinical trials conducted in different countries, with the participation of more than 500 subjects assessing the effectiveness of a low-calorie high-protein diet that include partial meal replacement in individuals with
Optimal fixed low-dose combination of glibenclamide and metformin
Abstract
Diabetes mellitus type 2 (T2DM) is a global problem of world health. Clinical studies show that early glucose-lowering therapy reduces the risk of complications, and recommend the use of lifestyle changes along with the initial combination therapy. Management of T2DM can be
Original research
Prediabetes and first diagnosed diabetes 2 types: metabolic and hemostatics aspects
Abstract
At the moment of verification of a type 2 diabetes mellitus (DM2) diagnosis, more than 50% of patients show clinical signs of atherosclerosis. Meanwhile, there have been no complex researches that seek to enable the estimation of the character and interrelations of the
Glargine 300 IU/ml (Toujeo) in patients with diabetes mellitus type 1 in a real outpatient practice: clinical features of practical use
Abstract
With diabetes mellitus type 1 (DM1), an absolute insulin deficiency is observed in the body due to the destruction of β -cells. Therefore, life-substituting insulin therapy is, to date, the only method for treating patients with this pathology. The leading role in the
Diabetic foot syndrome: a comparative analysis of the treatment at the stages of specialized medical care
Abstract
Management of patients with diabetes mellitus and diabetic foot syndrome represents a certain difficulty for the doctor, considering options general and local treatment, the need for long exposure, high economic component, both for the patient and his family, and for health
Assessment of chronic diabetic foot ulcers microbiome
Abstract
Aim - to compare the microbiome of chronic diabetic foot ulcers (DFU) without signs of infection using conventional culture techniques and mass - spectrometry approach of microbial markers. Material and methods. The samples from 17 DFU without signs of infection were sent to
Clinical and hormonal characteristic of constitutional delay ofpuberty in boys with obesity
Abstract
To examin the anthropometric and hormonal characteristic of constitutional delay of puberty (CDP) in boys with overweight/obesity. Methods. The study included 89 boys aged 14.5+0.8 years with CDP. The boys with deficiency weight were excluded from the study. The other
Clinical cases
The acute heart attack with the low cardiovascular risk: the disturbanse of the prandial carbohydrate metabolism and the other unrecorded factors
Abstract
The paper is devoted to the analysis of the case of the atypical acute myocardial infarction at the patient with the low cardiovascular risk and without the family history of cardiovascular events. It was shown that the development of the atypical acute myocardial infarction
Clinical case: the syndrome chiari-frames in a patient with history of hysterectomy
Abstract
The peculiarity of the clinical case is the difficulty of diagnosing the syndrome Chiari-Frommel in a patient previously operated on for the uterine fibroids.
Abstracts of research-to-practice conference for young scientists of the russian medical academy of postgraduate education ”Topical questions of endocrinology” (april 24, 2017)
Efficiency of integrated approach to therapy of type 2 diabetes mellitus
Abstract
The use of integrated approach in the treatment of type 2 diabetes mellitus (DM2) leads to improved glycemic and lipid control, by that reducing glucose and lipotoxicity, reducing oxidative stress, and improving body weight. Antioxidant therapy is pathogenetic in relation to
Decrease in men fertility after medulloblastoma complex treatment
Abstract
The structure and clinico-laboratorial characteristics of reproductive disorders in men who received complex therapy for neurogliocytoma were investigated. It was found that after therapy for neurogliocytoma in men, prevalence of reproductive system disorders is extremely
Carbohydrate metabolism parameters among railway transport foot-plate workers who had job on night shiftare
Abstract
Diabetes mellitus type 2 is a socially significant disease that increases the risk of development of disability and mortality of the able-bodied population. The prevalence of diabetes mellitus is steadily increasing, so that the importance of its prevention becomes more
Alpha-lipoic acid treatment in type 2 diabetes patients with diabetic polyneuropathy
Abstract
Clinical and laboratory efficacy of α-lipoic acid (ALA) in type 2 diabetes mellitus (DM2) patients with diabetic polyneuropathy (DPN) was evaluated. There were 59 DM2 patients with DPN under observation: 27 (45.8%) women and 32 (54.2%) men. 30 patients were additionally
Difficulties in diagnostics of TSH-producing pituitary adenoma. Clinical case
Abstract
Thyrotropinoma is a rare benign pituitary tumor. It appears only in 1-2% cases among all the pituitary hormone producing adenomas. Usually thyrotropinoma produces only one hormone, but sometimes (in 25%) it can produce many. Commonly the first symptoms of the disease are
Clinical and hormonal characteristics of delayed puberty in girls with hypergonadotropic hypogonadism
Abstract
Objectives - to study the clinical and hormonal characteristics of delayed puberty in girls with hypergonadotropic hypogonadism. Methods. 33 girls, 14.9 ± 0.7 years, with delayed puberty were examined. Entry criteria were the absence of secondary sex characteristics at
Real possibilities and prospects of the use of the metformin in patients with impaired carbohydrate metabolism
Abstract
Metformin is one of the most widely used antidiabetic drugs in the management of type 2 diabetes. The mechanism of action is well described, there are evidence of cardioprotective, antitumor and antiaging properties of the metformin. Moreover there areexpectations for
Effect of metformin on the level of homocysteine in the blood and vascular endothelial function in patients with type 2
Abstract
This article presents effect of metformin on homocysteine blood level and vascular endothelium function in patients with type 2 diabetes mellitus.
Primary аdrenal insufficiency. Clinical event
Abstract
Primary chronic adrenocortical insufficiency is quite rare in the general population - it occurs 40-110 times per 1 million population on annual basis. This clinical case describes the typical development of primary adrenal insufficiency of young male, its treatment with
Dynamics of antioxidant and metabolic status in patients with type 2 diabetes mellitus and male hypogonadism on the back of androgen therapy
Abstract
The work demonstrated a positive antioxidant activity against the background of hormone replacement therapy with testosterone in patients with type 2 diabetes mellitus and androgen deficiency.
Disorders of sex development 46,XY, androgen insensitivity syndrome: clinical and laboratory characteristics of patients
Abstract
Aim. To study clinical and laboratory characteristics of patients with disorders of sex development 46XY, androgen insensitivity syndrome. Subjects and methods. It was included 52 patients and formed group with disorders of sex development (DSD) 46XY, androgen insensitivity
The modern opinion on the diagnosis of obesity
Abstract
Obesity is one of the main health problems of our time. To identify the causes of the disease, various types of diagnostics are used. The aim of this work is to analyze these methods and based on their merits and demerits, to present a classification developed in 2014 that
Evaluation of C-peptide secretion effect on microcirculation parameters in type 2 diabetes mellitus
Abstract
We evaluated microcirculation parameters in patients with diabetes mellitus type 2 by digital capillaroscopy depending on the C-peptide secretion level. 1st group included patients with C-peptide <1000 pmol/l and 2nd group was consisted of patients with C