This review provides detailed information about history of the new class of antihyperglycemic drugs, inhibitors of DPP-4 appearance. Here are described main types of clinical researches conducted in Russia, which includes: effect of DPP-4 inhibitors on cardiac function in

Treatment of diabetes mellitus type 2 is a complex task. Monotherapy with oral hypoglycemic agents are not always achieves adequate glycemic control, and therefore the need to transition to a combination therapy of diabetes. The use of two or more medications significantly

Macrovascular complications of diabetes (the most common cause of death in the majority of patients) are one of the great challenges for modern diabetology. Insulin can potentially exert positive and negative biological effects on the cardiovascular system. ORIGIN (Outcome

Glucagon-like peptide-1 receptor (GLP-1R) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors represen t 2 distinct classes of incretin-based therapies used for the treatment of type 2 diabetes mellitus. Activation of GLP-1R signaling or inhibition of DPP-4 activity

In spite of advances in modern ophthalmology, the diabetic retinopathy and diabetic macular edema – the main reasons for a ablepsia of working age people in economically developed countries. Understanding of that all treatment mode of clinically significant diabetic

This article provides a definition of diffuse euthyroid goiter (DEG) and its classification. Diagnosis, etiology and pathogenesis of this disease are detailed described. Main strategies for DEG treatment, based on clinical trial data, are described: monotherapy with L

Reduced function of the thyroid gland causes Hypothyroidism which is further attributed to defects in the secretion of thyroid hormones triiodothyronine (T 3 ) and tetra-iodothyronine or thyroxine (T 4 ). T 3 and T 4 hormones are not only known to regulate the rate of

Recent advances in our understanding of geneticepigenetic interactions have unraveled new mechanisms underlying the etiology of complex autoimmune diseases. Autoimmune thyroid diseases (AITDs) are highly prevalent, affecting 1 % to 5 % of the population. The major AITDs

Vascular damage in diabetes mellitus is a serious complication that leads to the development of stroke, chronic cerebral ischemia, ischemic heart disease, angina pectoris, myocardial infarction, intermittent claudication, polyneuropathy, diabetic foot. Traditional

Complex nature of diabetes mellitus suggests further immersion in her study and fundraising timely feedback. The article presents the results of a study showing that in patients with diabetes mellitus type 2 who have not reached the target values of glycemia on metformin

In Russia more than 25% of obese individuals and more than 55% are overweight. Obesity increases the risk of the development of hypertension, diabetes mellitus type 2, arthragra, cancer and cardiovascular diseases, and also reduces longevity. From october 2012 to the present

In double-blind, placebo-controlled clinical trial taurine clinical efficacy in patients with non-alcoholic fatty liver disease and diabetes mellitus type 2 was evaluated. The results of this study have shown effects of taurine on lipid and carbohydrate metabolism and also