Эндокринология № 3 (40), 2022


News, Opinions, Training

Included into the List of the leading peer-reviewed journals and editions which are recommended by the State Commission for Academic Degrees and Titles of the Ministry of Education and Science of the Russian Federation for the publication of its results for competition of an academic degree of the candidate and doctor of science.

Topic number
3 . 2022
Endocrine disorder diagnosis and treatment: modern realities and prospects
Original research

Chemiluminescent activity of neutrophils in patients with Graves’ disease after 2-week withdrawal of thiamazole

Graves’ hyperthyroidism stimulates enhanced synthesis of reactive oxygen species (ROS) by phagocytic cells. The immunomodulatory effect of thionamide therapy has a short-term effect, which is realized at the onset of Graves’ hyperthyroidism, is associated with

Predictors of mortality in severe cases of coronavirus infection in patients with type 2 diabetes mellitus

Diabetes mellitus (DM) worsens the outcome of almost any acute or chronic disease, leading to a reduction in life expectancy. According to scientific data, diabetes mellitus leads to a 2–3-fold increase in the incidence of adverse disease outcomes. Mortality from

Modern realities and prospects of drug treatment of acromegaly

The continuing curation complexity of the curation of acromegaly is due to the multiplicity of pathomorphological variants of growth hormone-secreting adenomas and the lack of a differentiated approach when choosing a treatment strategy. The review presents up-to-date data

Endocrinology: past, present and future

Endocrinology is a relatively young medical science, that was formed in the late XIX – early XX century. The founder of Russian endocrinology is Professor Shervinsky V.D., who gave the endocrine disorders classes. The State Institute of Organotherapeutic Preparations

Modern methods of diagnosis and treatment of diabetic polyneuropathy

Diabetic sensorimotor polyneuropathy (DPN) is encountered in approximately one-third of people with diabetes. This, in turn, might markedly decrease their quality of life, mainly owing to neuropathic pain and foot ulcerations. Painful DPN might be as frequent as 25% in
To practitioner`s consult

Council of Experts Resolution of April 22, 2022 “Possibilities for use of a new HIF-PH inhibitor in patients with anemia in CKD”


Screening, diagnosis and treatment of diabetic sensorimotor polyneuropathy in clinical practice


Niche of the dipeptidyl peptidase 4 inhibitor alogliptin in hypoglycemic therapy of type 2 diabetes mellitus

The article provides an overview of the main drugs prescribed during management of patients with type 2 diabetes mellitus (T2DM) and separately considers the dipeptidyl peptidase‑4 (DPP‑4) inhibitor alogliptin. For many years, it has been assumed that intensive
Clinical cases

Hypo- and hyperglycemia: how to balance it?

Hyper- and hypoglycemia states are processes that are opposite in pathogenetic mechanisms, but have potentially negative consequences for the body. Insulinoma is a fairly rare disease, the clinical picture of which is associated with endogenous hyperinsulinism. This article

The path of patients with hyperprolactinemia in real clinical practice (clinical cases)

One of the most common endocrine disorders is hyperprolactinemia syndrome, which occurs due to the presence of a prolactin-secreting pituitary tumor. Excess production of prolactin, the volume and growth characteristics of macroprolactinomas cause a variety of clinical

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The effect of simultaneous pancreatic and kidney transplantation on the state of the retina in diabetes mellitus

Diabetic retinopathy (DR) is a microvascular complication of diabetes mellitus (DM), observed in every third patient with DM, and in every tenth is the cause of vision loss. It has been previously reported that the presence of DR increases the risk of diabetic nephropathy

Simultaneously detected papillary thyroid carcinoma and early pregnancy. Possible strategy

The most common type of thyroid cancer is papillary carcinoma. Differentiated thyroid cancer is a potentially curable disease with a good prognosis. When well-differentiated cancer during pregnancy is detected, the question of treatment strategy should be considered

Analysis of glycemic and lipid profiles, homocysteine levels in patients with metabolic syndrome in a pandemic of a new coronavirus infection

Coronavirus infection (CI) contributes to damage and disruption of the gastrointestinal tract and pancreas, which in turn leads to impaired carbohydrate metabolism, insulin resistance and increased blood glucose levels. Aim – to conduct a retro- and prospective

The prevalence of comorbid pathology in patients with type 2 diabetes mellitus

The study was conducted to assess the incidence of comorbid pathology in patients with type 2 diabetes mellitus. The study revealed the predominance of the following pathology: cardiovascular system, gastrointestinal tract, thyroid gland. The analysis showed that comorbidity

Link between cardiovascular risk and estradiol level in men

The aim of this study was to evaluate link between estradiol level and metabolic syndrome and cardiovascular risk factors in men. Patients in hyperestrogenic and control groups had comparable age, BMI and smoking status. Results of this study showed that hyperestrogenism in

Physiotherapy in the treatment of radiation reactions in a patient with type 2 diabetes mellitus. Clinical case

Diabetes mellitus is one of the most common comorbidities in patients with malignant neoplasms. During remote radiation therapy diabetes mellitus often contributes to the development of complications, which leads to a forced interruption of the radiation therapy course. This

The prevalence of diabetes in patients with acute necrotizing pancreatitis and exacerbation of chronic pancreatitis

Diabetes mellitus is declared as a “non-infectious epidemic” of the 21 st century, its prevalence is steadily increasing year by year, and the frequency of acute and chronic pancreatitis is similarly increasing. Hyperglycemia against the background of destruction

The role of insulin resistance and pancreatic β-cell dysfunction in development of prediabetes in obese adolescents

Obesity is one of the main risk factors for developing type 2 diabetes mellitus. The pathophysiology of type 2 diabetes mellitus is based on defective insulin secretion by pancreatic β -cells and the inability of insulin-sensitive tissues to respond appropriately to

The “metabolic memory” phenomenon in patients with diabetes mellitus and its significance (literature review)

The literature review is devoted to the significance of the «metabolic memory» phenomenon in patients with type 1 and type 2 diabetes mellitus. Based on large randomized trials the consequences of positive and negative «metabolic memory», which determine

Diabetes mellitus in the outcome of total pylorus-preserving pancreatoduodenectomy (therapeutic approach)

Any pathological process that causes pancreatic damage can lead to the development of carbohydrate metabolism disorders. Such processes include, for example, acute and chronic pancreatitis, injuries, pancreatic tumors and surgical interventions. This clinical case is of

Effect of antioxidant enzyme levels on the severity of diabetic polyneuropathy

The article discusses the effect of the level of antioxidant enzymes on the severity of diabetic polyneuropathy in patients with type 2 diabetes mellitus. As a result, it was shown that a decrease in the level of superoxide dismutase leads to an increase in neurological

Characteristics of cytokines in patients with type 2 diabetes mellitus and acute myocardial infarction

The paper analyzes the indicators of the inflammatory response in patients with type 2 diabetes mellitus (T2DM) and ST-segment elevation acute myocardial infarction (STEMI). According to the results of the study, it was revealed that in the group of patients with T2DM and

Differential diagnosis of follicular thyroid tumors with the use of core-needle biopsy

The study is devoted to the evaluation of the diagnostic capabilities of core-needle biopsy of follicular thyroid tumors. An analysis of the preliminary results of the study showed that ultrasound-guided core-needle in cases of follicular lesions (Bethesda IV cytology) is an

Effect of cholecalciferol supplementation on the clinical course of hospitalized COVID 19 patients

The aim of this study was to evaluate the effect of cholecalciferol supplementation on the clinical course of hospitalized patients with moderate-to-severe COVID‑19. Results showed the baseline prevalence of a low 25-hydroxyvitamin D level. We demonstrated that

Personalized approach to the treatment of acromegaly

The report reveals clinical and morphological patterns of secondary drug therapy (DT) with first-generation somatostatin analogues (SA1) and immunophenotypic factors of densely and sparsely granulated somatotroph adenomas, identified during immunohistochemical analysis (IHA)

The use of antioxidants in the treatment of purulent-necrotic complications of diabetic foot syndrome

The publication highlights the problem of purulent-necrotic complications of diabetic foot syndrome. Despite the fact that the etiology and pathogenesis of diabetic foot syndrome have been studied for a long time, statistical data on the frequency of complications remains

Experience of successful use of growth hormone receptor antagonist in the treatment of hereditary acromegaly as a part of McCune-Albright syndrome

Acromegaly is a severe disabling neuroendocrine disease caused by excessive production of somatotropin. Transnasal adenomectomy is a priority method of treatment. If it is impossible to perform a neurosurgical intervention, drug therapy with long-acting somatostatin

Features of the course of diabetes mellitus in the outcome of total pancreatectomy. Clinical case

Today, in modern diabetology, the most important condition for a personalized approach to patient management is accurate verification of the type of diabetes mellitus. Particular attention is drawn to a fairly large, but at the same time, insufficiently studied group of

Testicular adrenal rest tumors in the boy with congenital adrenal hyperplasia (case report)


A case of the testicular adrenal rest tumor in a 10-year-old boy with a salt-wasting form of congenital adrenal hyperplasia is described. The main diagnostic method was a testicular ultrasound examination.


News (# 3, 2022)


All-Russian scientific and practical conference “Life with diabetes from 0 to 100”


Vladimir O. Bondarenko (07.06.1960–15.08.2022)

Ametov Alexander S.
Honored Scientist of the Russian Federation, Doctor of Medical Sciences, Professor, Head of Subdepartment of Endocrinology, Head of the UNESCO Network Chair on the subject «Bioethics of diabetes as a global problem» of the Russian Medical Academy of Continuous Professional Education (Moscow)
Medicine today

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